PW03-011 – New Behçet's loci and gene-gene interactions
نویسندگان
چکیده
منابع مشابه
PW03-011 – New Behçet's loci and gene-gene interactions
Methods We used the Turkish collection GWAS genotypes to impute genotypes of 779,000 markers in the GWAS subjects and then evaluated the imputed markers for disease association. We also searched for new disease associated loci by analyzing patients with uveitis and by specifying different genetic models. We replicated the new BD loci in additional Turkish samples (838 cases, 630 controls) and i...
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Gene x environment (G x E) interactions mediating depressive symptoms have been separately identified in the stress-sensitive serotonergic (5-HTTLPR) and corticotropin-releasing hormone (CRHR1) systems. Our objective was to examine whether the effects of child abuse are moderated by gene x gene (G x G) interactions between CRHR1 and 5-HTTLPR polymorphisms. We used an association study examining...
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Genome-wide association studies (GWAS) have identified more than a dozen loci associated with colorectal cancer (CRC) risk. Here, we examined potential effect-modification between single-nucleotide polymorphisms (SNP) at 10 of these loci and probable or established environmental risk factors for CRC in 7,016 CRC cases and 9,723 controls from nine cohort and case-control studies. We used meta-an...
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Introduction The inflammasome complex and the inflammatory pathway have been implicated in the pathogenesis of familial Mediterranean fever (FMF), and recently ASC (apoptosis-associated speck-like protein containing a CARD) mRNA expression was found to be up-regulated in patients carrying MEFV mutations independent of the mutation type. Gene-expression profiling has the capacity to reveal trans...
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ژورنال
عنوان ژورنال: Pediatric Rheumatology
سال: 2013
ISSN: 1546-0096
DOI: 10.1186/1546-0096-11-s1-a237